The Leeds Teaching Hospitals NHS Trust

Second Highest Recruiting Centre for REDUCE FMR Study

Friday 6th October 2017

The Leeds Teaching Hospitals cardiovascular research team are the second highest recruiters for a study that could improve the quality of life for patients with heart failure.

More than 20 million people suffer from heart failure worldwide and the number is growing rapidly. People with heart failure develop heart enlargement which can lead to problems with the mitral valve in the heart. This can sometimes be a condition called functional mitral regurgitation, which is when the mitral valve doesn’t close tightly so blood flows backward towards the lungs causing symptoms including shortness of breath and fatigue.


The Reduce FMR study is a trial to assess the safety and efficacy of the Carillon Mitral Contour System. The Carillon implant is placed in a vein on the outside of the heart which is next to the mitral valve. This is a simple low risk procedure designed to reshape the mitral valve and reduce leakage.

In current practice, the treatment options include tablets, high risk surgical repair of the valve and the use of a non-surgical device which is not suitable for all patients, so the new Carillon implant could make a real difference to the quality of life for patients with heart failure.