Neurology Research Studies

project title	UK MS Register
project aims	To build a longitudinal database of at least 3000 people with Multiple Sclerosis (MS) in the UK, consisting of linked data from clinicians, people with MS and routine MS data.
start date	23/05/2011
local target	400
current recruitment	340
main contact	Dr Helen Ford (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information	Additional Questionnaires available via ukmsregister.org

project title	Identification of Biomarkers of MS and its’ Subtypes
project aims	To investigate molecular changes in the blood in order to identify a subset of molecules that can be measured in the blood and provide a simple and cost-effective tool for MS Diagnosis including delineating between the MS subtypes (RRMS, PPMS and SPMS).
start date	01/05/2018
local target	120
current recruitment	101
main contacts	Dr Oliver Lily (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information	A collaboration with the University of Huddersfield. Involves the patient having blood taken.

project title	MS STAT 2
project aims	To test the effectiveness of re-purposed Simvastatin (80mg) in a phase 3 double blind, randomised, placebo controlled trial (1:1 ratio active to placebo) in patients with SPMS, to determine if the rate of disability progression can be slowed over a 3 year period.
start date	13/07/2018
local target	48
current recruitment	41
main contacts	Dr Helen Ford (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information

project title	TONiC (Trajectories of Outcomes in Neurological Conditions)
project aims	To develop a biopsychosocial model of factors affecting quality of life (QoL) in different neurological conditions: multiple sclerosis (MS), motor neurone disease (MND), neuromuscular (NM) disorders, traumatic brain injury (TBI), spinal conditions, stroke and neuromyelitis optica (NMO).
start date	13/10/2014
local target	30
current recruitment	91
main contacts	Dr Helen Ford (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information	Additional Information available at tonicstudy.org

project title	DELIVER-MS
project aims	DELIVER-MS seeks to answer an important question: Does early treatment with Disease Modifying Treatment(s) (DMTs) improve prognosis for people with MS? This is an area of controversy and no scientific data exists to guide treatment choices for patients and clinicians.
start date	04/04/2019
local target	20
current recruitment	3
main contacts	Dr Oliver Lily (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information	Each site must recruit identical numbers of patients who are randomised and patients on the observational arm.

project title	MuSicalE (A Multi-centre Non-interventional Study to Assess the Real-world Effectiveness of Ocrelizumab in Patients with RPMS or PPMS)
project aims	The MuSicalE Study will help in answering the following research question - How effective is Ocrelizumab in the treatment of RPMS and PPMS when used in routine clinical practice?
start date	21st March 2019
local target	10
current recruitment	6
main contacts	Dr Maruthi Vinjam (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information

project title	LEMTRADA PASS (A prospective, multicentre, observational, post-authorization safety study (PASS) to evaluate the long term safety profile of LEMTRADA treatment in patients with relapsing forms of multiple sclerosis.)
project aims	The overall goal of the study is to better characterise the long-term safety profile of Lemtrada® (Alemtuzumab) treatment in relapsing multiple sclerosis (RMS) patients and to determine the incidence of adverse events of special interest (AESI).
start date	16/11/2015
local target	5
current recruitment	5
main contacts	Dr Oliver Lily (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information

project title	MolGen (Molecular Genetics of Adverse Drug Reactions)
project aims	Previous Studies have shown that genetic factors play an important role in the predisposition to adverse drug reactions. The results of the MolGen Study will help to determine and clarify clinical validity and the future utility of genetic tests.
start date	01/12/2010
local target	5
current recruitment	39
main contacts	Dr Melissa Maguire (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information

project title	BioJuME (Biology of Juvenile Myoclonic Epilepsy)
project aims	The goal of the BioJuME study is to find the genetic basis for susceptibility to seizures and associated co-morbidities for Juvenile Myoclonic Epilepsy using genome-wide association approaches.
start date	04/07/2017
local target	10
current recruitment	18 in Adults
main contacts	Dr Melissa Maguire (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information	An additional 3 patients have been recruited by the Paediatric Research Department.

project title	Eslicarbazepine (Eslicarbazepine and Cognition in Older Patients)
project aims	To evaluate the effect of Eslicarbazepine on cognition in older patients with epilepsy. Assessments will be performed at baseline, three months and six months after commencement of Eslicarbazepine.
start date	November 2019
local target	3
current recruitment	0
main contacts	Dr Melissa Maguire (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information

project title	PD Families (Parkinson’s Families Project)
project aims	PD Families aims to identify genetic variants that predispose to or cause Parkinson’s disease (PD) or Parkinsonism and also to identify families that may be prepared to participate in translational research related to PD, its aetiology, biology, progression and future treatment.
start date	22/10/2015
local target	15
current recruitment	19
main contacts	Dr Stuart Jamieson (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information

project title	PD ProSPeCt-M-UK (Progressive Supranuclear Palsy Cortico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK)
project aims	To recruit up to 49 patients/year with early atypical parkinsonian clinical (APC) syndromes which do not fulfill existing criteria for PSP-RS/CBS-CBD/MSA but which may represent variant clinical syndromes related to tau pathology including pure akinesia with gait freezing (PAGF), PSP-parkinsonism, overlap syndromes and atypical parkinsonian disorders not meeting clinical diagnostic criteria at entry.
start date	26/04/2018
local target	8
current recruitment	4
main contacts	Dr Ioannis Mavroudis (Principal Investigator) Neurology Research Team ext: 0113 39 23468
additional information

project title	PD Vision (Disruption of Visual Processing in Parkinson’s Disease)
project aims	The PD Vision Study aims to test key hypotheses set out in the objectives of the study. The key hypotheses of this study are as follows: Visual processing is disrupted in Parkinson’s disease and this can be detected at the very earliest stages of the disease. Patients carrying some genetic mutations will show greater deficits in visual processing than those carrying other genetic mutations. Visual disruption will correlate with other markers of Parkinson’s disease such as presence or absence of tremor, or with worse cognition. Visual disruption will deteriorate with disease progression, allowing tracking of the disease over time and forming outcome measures for clinical trials.
start date	13/11/2018
local target	30
current recruitment	29
main contacts	Dr Jeremy Cosgrove (Principal Investigator) Neurology Research Team: 0113 39 23468
additional information

University of Leeds

Leeds City Council

Leeds Academic Health Partnership

West Yorkshire and Harrogate Health and Care Partnership

Leeds Cancer Programme

Leeds Care Record