Carbohydrate deficient transferrin (CDT)
**This test is not routinely available. Please call the Duty Biochemist to discuss, 0113 39 26922 option 2**. Indication for requesting: to discriminate between alcohol-induced hepatotoxicity and liver disease of other origin. The majority of transferrin in the blood has 3-5 carbohydrate side-chains. CDT refers to transferrin with 0-2 sidechains, which usually represents < 2.6% of the total. Alcohol inhibits glycosyl transferase and stimulates sialidase enzymes in the liver, resulting in an increase of CDT in the blood. CDT is a more sensitive and specific indicator for recent consumption of alcohol than GGT. CDT remains in the circulation for 7-14 days. CDT may also be increased in advanced cholestatic liver disease due to reduced removal, and in carbohydrate deficient glycoprotein syndromes.
| Tube | 01 (SE) - Serum Gel |
|---|---|
| ID | Tests&Tubes0164 |
| Additional Information | Not available for requests relating to DVLA enquiries. |
| Turn Around | Turnaround time stated by Sheffield Pru: 5 days. |
| Send to | Blood Sciences LGI (Test referred to: Sheffield Protein Reference Unit (PRU).) |
| Contact | For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net. |
| Advice | Full Referred Test details logged internally on the referred test database [BSF2REC17003]http://leedspath.myeqms.com/Administrator/LoadDocADM.asp?ID=82998&Ext=True&CCID=1 |
| Collection Con | Minimum Volume: 2ml serum. Instructions to lab: Centrifuge sample, separate serum and store in fridge. |
| Sample REQ | Blood |
| Ref. Range Notes | 0 - 2.6% |
| Units | % |
| Telepath | SCDT1R & SA1R |
