Clobazam
Clobazam is one of the benzodiazepines. Most commonly used as an oral antiepileptic. Indication for requesting: therapeutic drug monitoring (TDM). Clobazam has a wide therapeutic window. As tolerance can develop there is no clear relationship between plasma concentration and efficacy. Norclobazam is less potent that clobazam but retains some anti-epileptic activity.
| Tube | 04 (EP) - EDTA Plasma |
|---|---|
| ID | Tests&Tubes0171 |
| Additional Information | No correlation between either seizure control or toxicity has yet been established, but the majority of patients receiving treatment with conventional doses of clobazam have plasma concentrations below 200 µg/L for the parent drug and 2000 µg/L for the desmethyl metabolite. Desmethylclobazam has a longer half-life and therefore reaches higher plasma concentration. |
| Turn Around | Turnaround time stated by Cardiff: 7 days |
| Send to | Blood Sciences LGI (Test referred to: Cardiff toxicology lab) |
| Contact | For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net. |
| Advice | Full information on all referred tests can be found on the referred tests information database, EQMS reference BSF2REC17003. |
| Collection Con | Instructions to lab: Centrifuge sample, separate and freeze plasma. Serum gel tubes are not suitable. Minimum volume: 1 mL plasma |
| Sample REQ | Blood |
| Ref. Range Notes | 50 - 300 ug/L |
| Units | ug/L |
| Telepath | LCLOB / JCLOB |
| ICE Codes | LCLOB / JCLOB |
