Clobazam is one of the benzodiazepines. Most commonly used as an oral antiepileptic. Indication for requesting: therapeutic drug monitoring (TDM). Clobazam has a wide therapeutic window. As tolerance can develop there is no clear relationship between plasma concentration and efficacy. Norclobazam is less potent that clobazam but retains some anti-epileptic activity.
|Tube||04 (EP) - EDTA Plasma|
|Additional Information||No correlation between either seizure control or toxicity has yet been established, but the majority of patients receiving treatment with conventional doses of clobazam have plasma concentrations below 200 µg/L for the parent drug and 2000 µg/L for the desmethyl metabolite. Desmethylclobazam has a longer half-life and therefore reaches higher plasma concentration.|
|Turn Around||Turnaround time stated by Cardiff: 7 days|
|Send to||Blood Sciences LGI
(Test referred to: Cardiff toxicology lab)
|Contact||For further details please contact Leeds Pathology customer services: firstname.lastname@example.org.|
|Advice||Full information on all referred tests can be found on the referred tests information database, EQMS reference BSF2REC17003.|
|Collection Con||Instructions to lab: Centrifuge sample, separate and freeze plasma. Serum gel tubes are not suitable.
Minimum volume: 1 mL plasma
|Ref. Range Notes||50 - 300 ug/L|
|Telepath||LCLOB / JCLOB|
|ICE Codes||LCLOB / JCLOB|