Free fatty acids (FFA) & β-hydroxybutyrate (D3HB)
3-hydroxybutyrate is one of three ketone bodies generated from free fatty acids via ketogenesis. Both free fatty acids and beta-hydroxybutyrate are analysed on the sample. Clinical indications for request: ? Hyperinsulinism, ? Fat oxidation defects (e.g. MCADD), ? Ketolytic defects (e.g. beta ketothiolase deficiency), ketoacidotic states (e.g. alcoholic).
|Tube||07 (FP) - Fluoride Oxalate Plasma|
|Additional Information||Please collect into a fluoride oxalate (grey-topped) tube. Serum samples can also be accepted.
For the investigation of ?hyperinsulinism or ?fat oxidation defect, the plasma glucose should be <2.5 mmol/L at the time of sampling for analysis to be valid.
For ?ketolytic defect investigations, the test should be performed whatever the glucose.
For hyperinsulism, fat oxidation defects and ketolytic defects refer to Paediatric Biochemist at SJUH (ext 64256).
|Turn Around||Turnaround time stated by Edinburgh Royal Infirmary: 5 days|
|Send to||Blood Sciences LGI
(Test referred to: Edinburgh Royal Infirmary.)
|Contact||For further details please contact Leeds Pathology customer services: email@example.com.|
|Advice||Full information on all referred tests can be found on the referred tests information database, EQMS reference BSF2REC17003.|
|Collection Con||Instructions to lab: Centrifuge, separate and freeze plasma.
Minimum volume: 0.5 mL plasma/serum.
|Ref. Range Notes||FFA: 0.1 - 0.6 mmol/L. BOHB: < 0.4 mmol/L. Will be reported with an interpretive comment.|
|Telepath||LGI superset LFFAP. SJUH superset JFFAP.|