The Leeds Teaching Hospitals NHS Trust

Parathyroid hormone related protein (PTHrp)

A form of PTH produced in tumours which is highly bioactive but may not be detectable in routine assays. If a patient is hypercalcaemic and has a raised PTHrP they have a 99% chance of having a malignancy (very specific). If PTHrP is elevated this is the main cause of the hypercalcaemia in the vast majority of these cases. It should be noted however that 12- 15% of patients with PTHrp malignancy may have concurrent primary hyperparathyroidism, treatment of which can result in normalisation of the calcium.

Tube EDTA tube containing protease inhibitor
ID Tests&Tubes0227
Additional Information PTHrp is only available after discussion with the Duty Biochemist (0113 39 26922 option 2). ***Please see information for collection conditions***
Turn Around Turnaround time stated by Biomnis: 21 days.
Send to Blood Sciences LGI
(Test referred to: Biomis (France))
Contact For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net.
Collection Con Sample must be collected during normal working hours. Please collect a special EDTA tube containing protease inhibitor from the Endocrinology lab, block 46, SJUH (x67043). The sample must be collected into this special tube and returned to the Endocrinology lab on wet ice within 30 min of collection. Instructions to lab: The sample should be booked in by the Endocrinology BMS. Spin in a refrigerated centrifuge, separate plasma into a labelled secondary tube and freeze. Add comment on notepad that sample was processed correctly. Scan request card. Send the tube containing frozen plasma on dry ice to LGI specimen reception, marked ‘to store in referrals section of freezer’.
Sample REQ Blood
Ref. Range Notes <1.4 pmol/L
Units pmol/L
Telepath PTHP1R & SA1R