The Leeds Teaching Hospitals NHS Trust

Proinsulin

Proinsulin

Clinical indication for request: Suspicion of an insulinoma. Pro-insulin is secreted in excess by insulinomas due to a shortened storage phase. Pro-insulin has 10% of the hypoglycaemic effect of insulin, but it accounts for 25% of immunoreactive insulin.

Tube 01 (SE) - Serum Gel
ID Tests&Tubes0238
Additional Information Excess levels reliably indicate an insulinoma. High proportion of pro-insulin to insulin indicates an undifferentiated tumour e.g. an islet cell carcinoma.
Turn Around Turnaround time stated by Guildford: 2 weeks
Send to Blood Sciences LGI
(Test referred to: Guildford biochemistry lab.)
Contact For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net.
Collection Con Sample must be received in the lab within 1h of collection. A fluoride sample for plasma glucose is also required. Instructions to lab: Centrifuge sample, separate serum and store in freezer within 1h of sample collection. Lithium heparin plasma is also acceptable.
Sample REQ Blood
Ref. Range Notes < 10 pmol/L
Units pmol/L
Telepath No code. Book in as PROB1L (comment NRSOT) & SA1R