Proinsulin
Clinical indication for request: Suspicion of an insulinoma. Pro-insulin is secreted in excess by insulinomas due to a shortened storage phase. Pro-insulin has 10% of the hypoglycaemic effect of insulin, but it accounts for 25% of immunoreactive insulin.
| Tube | 01 (SE) - Serum Gel |
|---|---|
| ID | Tests&Tubes0238 |
| Additional Information | Excess levels reliably indicate an insulinoma. High proportion of pro-insulin to insulin indicates an undifferentiated tumour e.g. an islet cell carcinoma. |
| Turn Around | Turnaround time stated by Guildford: 2 weeks |
| Send to | Blood Sciences LGI (Test referred to: Guildford biochemistry lab.) |
| Contact | For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net. |
| Advice | Full information on all referred tests can be found on the referred tests information database, EQMS reference BSF2REC17003. |
| Collection Con | Sample must be received in the lab within 1h of collection. A fluoride sample for plasma glucose is also required. Instructions to lab: Centrifuge sample, separate serum and store in freezer within 1h of sample collection. Lithium heparin plasma is also acceptable. Minimum volume: 0.1mL serum. |
| Sample REQ | Blood |
| Ref. Range Notes | < 10 pmol/L in hypoglycaemia. |
| Units | pmol/L |
| Telepath | No code. Book in as PROB1L (comment NRSOT) & SA1R |
