Alpha-1-Antitrypsin (AAT)
Measurement of alpha-1 antitrypsin is useful in the investigation of emphysema and unexplained liver disease in adults. In paediatric practice, alpha-1 antitrypsin deficiency may be associated with neonatal jaundice.
NOTE Inflammatory conditions may mask deficiency as AAT is an acute phase reactant. Increased levels also occur in malignancy, pregnancy and those taking exogenous oestrogens.
| Tube | Serum Gel |
|---|---|
| ID | 12749 |
| Availability | Weekdays |
| Additional Information | Deficiency leads to chronic obstructive airways disease, emphysema, neonatal/juvenile liver disease. Samples with an AAT concentration of 0.9g/L or below will undergo phenotypic analysis by isoelectric focusing to determine if the patient has one or more (heterozygosity or homozygosity) AAT deficiency alleles. Users will be asked to contact the lab if alpha1-antitrypsin levels are borderline to clarify if phenotyping is required. Note, AAT levels may be within normal range in paediatric patients, therefore if there is a strong suspicion of AAT deficiency AAT phenotyping should also be performed. |
| Turn Around | 7 days |
| Send to | Clinical Immunology Floor E, Old Medical School, LGI Great George Street Leeds LS1 3EX |
| Contact | https://www.leedsth.nhs.uk/a-z-of-services/pathology/specialist-laboratory-medicine-slm/immunology-laboratory/ |
| Advice | https://www.leedsth.nhs.uk/a-z-of-services/pathology/specialist-laboratory-medicine-slm/immunology-laboratory/ |
| Collection Con | No restrictions If result is low the Immunology laboratory will add phenotyping test |
| Frequency | Daily |
| Sample REQ | Blood |
| Ref. Range (Male) | 1.1 - 2.1 (Adult) |
| Ref. Range (Female) | 1.1 - 2.1 (Adult) |
| Ref. Range (Paed) | See notes |
| Ref. Range Notes | Day 1 to 26 weeks = 0.9-2.2 26 weeks to 1 years = 0.8-1.8 1 years to 5 years= 1.1-2 5 years to 10 years = 1.1-2.2 10 years to 15 years = 1.4-2.3 15 years to adult= 1.2-2 |
| Units | g/L |
| IP Acute TAT | 7 days |
| IP Routine TAT | 7 days |
| GP Acute TAT | 7 days |
| GP Routine TAT | 7 days |
| Telepath | AAT1L |
| ICE Codes | IAAT |
