The Leeds Teaching Hospitals NHS Trust

Anti-DNA antibodies

Anti-DNA antibodies

Anti-double stranded DNA Ab are a highly sensitive and specific diagnostic marker of SLE. They are the most frequently detected autoAb associated with SLE. Positive anti-DNA antibodies are found in 70-90% of patients with SLE and tend to correlate with disease activity. Raised levels may also be seen in a small minority of patients with autoimmune hepatitis. A negative dsDNA Ab does not rule out the diagnosis of SLE.

Tube Serum Gel
ID 12762
Availability Weekdays
Additional Information Indicated in the diagnosis and monitoring of SLE. Anti-DNA antibody test is now included in the anti-nuclear antibody (ANA) screen performed on the Bioplex 2200, an automated multiplex analyser. The ANA screen can determine autoantibodies against anti-DNA, Ro (60 and 52kDa), La, Sm, Sm/RNP, RNP (68KDa), Scl-70, Jo-1, CENP-B, chromatin and ribosomal P Ab. For each result the ANA screen is reported as either POSITIVE or NEGATIVE, AND a value for the anti-DNA Ab and each of the ENAs is given. The ANA screen is positive if either the DNA Ab and/or one of more ENA Ab specificities are positive.
Turn Around 7 days
Send to Leeds General Infirmary
Clinical Immunology
Old Medical School
Great George Street
Leeds
LS1 3EX
Collection Con No restrictions
Frequency Daily
Sample REQ Blood
Ref. Range (Male) See reference range note
Ref. Range (Female) See reference range note
Ref. Range (Paed) See reference range note
Ref. Range Notes 10 IU/ml and above is POSITIVE
Units IU/mL
IP Acute TAT - Contact Laboratory
IP Routine TAT 7 days
GP Acute TAT - Contact Laboratory
GP Routine TAT 7 days
Telepath ANAS1L
ICE Codes IANA