Anti-Neutrophil Cytoplasmic Antibodies (ANCA) Screen: Anti-MPO and PR3 Ab
Positive ANCA is associated with small vessel vasculitis. Indicated in Wegner's Granulomatosis, Microscopic Polyarteritis, Churg-Strauss syndrome. Screening for ANCA-associated small vessel vasculitis with anti-MPO and PR3 AB. Positive results willhave an ANCA test by indirect immunofluorescence.
| Tube | Serum Gel |
|---|---|
| ID | 12784 |
| Availability | Weekdays |
| Additional Information | Two patterns are identifed by indirect immunofluroescence (IIF) - cytoplasmic (C-ANCA) and perinuclear (P-ANCA). Levels of MPO/PR3 also correlate with disease activity. P-ANCA with anti-MPO are found in approximately 70% of patients with Churg-Strauss and Microscopic Polyarteritis. C-ANCA/anti-PR3 are found in approximately 85% of patients with Wegener's. |
| Turn Around | 7 days |
| Send to | Leeds General Infirmary Clinical Immunology Old Medical School Great George Street Leeds LS1 3EX |
| Collection Con | No restrictions |
| Frequency | Daily |
| Sample REQ | Blood |
| Ref. Range (Male) | <1 AI |
| Ref. Range (Female) | <1 AI |
| Ref. Range (Paed) | <1 AI |
| Ref. Range Notes | <1AI (Antibody index is negative for anti-MPO and PR3 Ab. |
| Units | AI |
| IP Acute TAT | - Contact Laboratory |
| IP Routine TAT | 7 days |
| GP Acute TAT | - Contact Laboratory |
| GP Routine TAT | 7 days |
| Telepath | ANC1L |
| ICE Codes | IANCA |
