C1 Esterase Inhibitor
Immunochemical levels C1 esterase inhibitor are assessed along with complement C3 and C4. If results indicate, a functional assay will be performed with an appropriate sample.
| Tube | Serum Gel |
|---|---|
| ID | 12757 |
| Availability | Weekdays |
| Additional Information | Indicated in the investigation of anginoneurotic / hereditary/ acquired angioedema. Recurrent episodes of nonpruritic, nonpitting, subcutaneous or submucosal oedema typically involving the arms, legs, hands, feet, bowels, genitalia, trunk, face, tongue, or larynx. C1 esterase inhibitor deficiency is transmitted as an autosomal dominant disorder resulting in Hereditary Angioedema (HAE). A rare, acquired form (AAE) may occur with lymphoproliferative disease and Autoimmune disorders. Two inherited forms exist: in classic Type 1 deficiency C1 esterase levels are low whereas in the less common Type 2 deficiency C1 esterase is produced but is not functional. Samples collected during an acute attack of angioedema due to C1 inhibitor deficiency have a very low C4 level and thus a normal C4 virtually excludes the condition. |
| Turn Around | 7 days |
| Send to | Leeds General Infirmary Clinical Immunology Old Medical School Great George Street Leeds LS1 3EX |
| Collection Con | No restrictions however the functional assay requires a serum sample frozen within one hour of collection. |
| Frequency | Daily |
| Sample REQ | Blood |
| Ref. Range (Male) | 0.15 - 0.35 |
| Ref. Range (Female) | 0.15 - 0.35 |
| Ref. Range (Paed) | 0.15 - 0.35 |
| Units | g/L |
| IP Acute TAT | - Contact Laboratory |
| IP Routine TAT | 7 days |
| GP Acute TAT | - Contact Laboratory |
| GP Routine TAT | 7 days |
| Telepath | CIN1L |
| ICE Codes | ICIN |
