Complement C2
C2 is a component of the classical Complement activation pathway. It is cleaved by activated C1s into two fragments, C2a and C2b. C2a combines with C4b to form C3 and C5 convertase.
Genetic deficiency of C2 is the most common complement deficiency and is nearly always caused by a 28bp deletion in the C2 gene [2]. C2 deficiency is associated with SLE, glomerulonephritis, and vasculitis [1]. Approximately 25% of C2 homozygote deficient patients are susceptible to severe infections. Reductions in C2 can also arise due to consumption following classical complement pathway activation [3].
| Tube | Serum Gel |
|---|---|
| Availability | Weekdays |
| Turn Around | Refer to relevant laboratory for up to date turn around times, allowing an additional 10 working days for samples processing, dispatch and reporting and validation of the results |
| Send to | Samples should be sent to the department of Clinical Immunology at LGI who will refer to appropriate referral lab (Sheffield PRU) |
| Contact | https://www.leedsth.nhs.uk/a-z-of-services/pathology/specialist-laboratory-medicine-slm/immunology-laboratory/ |
| Advice | https://www.leedsth.nhs.uk/a-z-of-services/pathology/specialist-laboratory-medicine-slm/immunology-laboratory/ |
| Collection Con | Sample separated within one hour of collection and frozen as soon as possible. Inform immunology immediately. |
| Frequency | Referred to external laboratory |
| Sample REQ | Blood |
| Ref. Range Notes | See reference range on referral website |
| Units | See reference range on referral website |
| Telepath | CC21L |
| ICE Codes | CC21L |
