Cryoglobulins are immunoglobulins which reversibly precipitate in the cold. Type I (monoclonal) cryoglobulins are associated with B-cell lymphoma and myeloma whilst mixed cryoglobulins (type II and III) are associated with infective and inflammatory disorders. Cryoprecipitates are more commonly of mixed type and are immune complexes causing a vasculitis, synovitis or glomerulaneohritis in association with a connective tissue disorder and certain infections. Consider cryoglobulinaemia in any patient with unexplained vasculitis
|Additional Information||The requesting doctor (or phlebotomy) should contact Immunology reception (LGI x23414 or SJUH x64579) to inform staff that they wish to take a cryoglobulin sample. Reception staff will prepare an insulated flask containing water warmed to 40oC.
This insulated flask will be collected from Clinical Immunology Reception (Old Medical School, LGI) or Transplant Immunology Reception (Gledhow Wing, SJUH) by the requesting doctor or phlebotomist just prior to sample collection. Once the patient has been bled the sample will be immediately transported in the flask back to Clinical or Transplant Immunology. When first identified the cryoglobulin type will be indicated where possible.
|Turn Around||10 days|
|Send to||Leeds General Infirmary
Old Medical School
Great George Street
|Collection Con||It is essential to collect a sample in an Immunology tube, immerse it in a flask of water at 37C and bring to the laboratory asap. Please warn the laboratory of its impending arrival.|
|Ref. Range (Male)||NA - Inerpretive|
|Ref. Range (Female)||NA - Inerpretive|
|Ref. Range (Paed)||NA - Inerpretive|
|Ref. Range Notes||Positive/Negative. Cryoglobulin type (I, II or III) where possible.
|Units||- Not Defined -|
|IP Acute TAT||NA|
|IP Routine TAT||10 days|
|GP Acute TAT||NA|
|GP Routine TAT||NA|