Myositis associated autoantibodies
Idiopathic inflammatory myopahies are an inflammatory disease of skeletal muscles. These myopathies can be divided into polymyositis, dermatomyositis, idiopathic myositis, anti-synthetase syndrome and overlap syndrome.
| Tube | Serum Gel |
|---|---|
| ID | 12789 |
| Additional Information | This assay detects autoantibodies to 11 different myositis associated antigens: Jo-1, Mi-2alpha and Mi-2beta, TIF1gamma (transcriptional intermediary factor), MDA5 (melanoma differentiation-associated gene 5), XNP2, SAE (SAE1/2), Ku, PM-Scl100, PM-Scl75, SRP (signal recognition particle), PL-7, PL-12, EJ. OJ and Ro-52. Anti-Jo-1 Ab are found in polymyositis, often occur simultaneously in autoimmune diseases such as SLE, systemic sclerosis or interstitial lung fibrosis. Mi-2 Ab are highly specific for dermatomyositis. Anti- Jo-1, PL-7, PL-12 EJ and OJ antibodies are associated with anti-synthetase syndrome. Anti-SRP Ab is a marker for immune-mediated necrotising myopathy. Anti-PM-Scl 75 and 100 Ab are associated with overlap syndrome which manifests as a combination of polymyositis, dermatomyoitis and systemic sclerosis symptoms. Anti-Ro52 Ab are not associated with a specific disease, but can be found in both autoimmune and infectious diseases. |
| Send to | Leeds General Infirmary Clinical Immunology Old Medical School Great George Street Leeds LS1 3EX |
| Collection Con | Stricktly, only available following discussion with Clinical Immunology |
| Frequency | Every fortnight |
| Sample REQ | Blood |
| Ref. Range (Male) | Na - Interpretive |
| Ref. Range (Female) | Na - Interpretive |
| Ref. Range (Paed) | Na - Interpretive |
| Ref. Range Notes | Positive/Negative |
| Units | NA |
| IP Acute TAT | - Contact Laboratory |
| IP Routine TAT | 14 days |
| GP Acute TAT | - Contact Laboratory |
| GP Routine TAT | 14 days |
| Telepath | IBM3L |
| ICE Codes | IBM |
