Systemic Sclerosis Antibody Profile
Scleroderma (systemic sclerosis) is a complex disease associated with extensive fibrosis, vascular alterations and autoantibodies against various cellular antigens. There are two major subgroups: limited cutaneous scleroderma (lcSSc) (skin involvement limited to distal extremities) and diffuse cutaneous scleroderma (dcSSc) (symptoms diffusely distributed over trunk, distal and proximal extremities and the face). Scleroderma can also lead to dysfunction/failure of internal organs.
| Tube | Serum Gel |
|---|---|
| ID | 12793 |
| Availability | Weekdays |
| Additional Information | This assay detects autoantibodies to 13 different scleroderma associated antigens: Scl-70, CENP A, CENP B, RP11 and RP155 (RNA polymerase III subunits), Fibrillarin, NOR90, Th/To, PM-Scl 100, PM-Scl 75, Ku, PDGFR (Platelet derived growth factor receptor) . Anti-Scl-70 Ab can be detected in up to 65% of patients with dcSSc. Anti-centromere Ab are most commonly associated with lcSSc and are detected in up to 82% of these patients. PM-Scl 100 and 75 Ab can be found on SSc and dermato-/polymyositis. The other autoantibodies are less prevalent in SSc. Anti-Ro52 Ab are not associated with a specific disease, but can be found in both autoimmune and infectious diseases. |
| Turn Around | 14 days |
| Send to | Leeds General Infirmary Clinical Immunology Old Medical School Great George Street Leeds LS1 3EX |
| Collection Con | Available only after discussion with a Consultant Immunologist |
| Frequency | Every fortnight |
| Sample REQ | Blood |
| Ref. Range (Male) | NA Interpretive |
| Ref. Range (Female) | NA Interpretive |
| Ref. Range (Paed) | NA Interpretive |
| Ref. Range Notes | Positive/Negaitve |
| Units | NA |
| IP Acute TAT | - Contact Laboratory |
| IP Routine TAT | 14 days |
| GP Acute TAT | - Contact Laboratory |
| GP Routine TAT | 14 days |
| Telepath | IBN1L |
| ICE Codes | IBN |
