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Tryptase (Mast Cell)

Anaphylactic reactions (IgE dependant or non-IgE dependant) are mediated by the release of vasoactive mediators, including tryptase, from mast cells and circulating basophils. Serial measurements of Tryptase are made to determine if a mast cell-mediated reaction to the anaesthetic is evident and the investigation of anaphylactic reactions requires 3 serial samples (see collection conditions).

Tube	Serum Gel
ID	12799
Availability	Weekdays
Additional Information	Tryptase levels usually peak within an hour and has an in vivo half-life of 2.5 hours, returning to normal within 12-24 hours after release. Plasma tryptase can be elevated in systemic mastocytosis. Here levels tend to be constantly raised. Mastocytosis is a rare disorder. The presence of systemic mast cell degranulation is evidenced by an increase in serum tryptase however tryptase levels are persistently elevated in mastocytosis therefore random measurements are difficult to interpret. Please contact the Immunology Lab 0113 39 23414 (between 08:30 and 17:00) to advise them a sample has been sent.. If sending out of hours, please contact the main lab on 0113 39 26745 to advise them a sample has been sent Please contact the laboratory for interpretive advice on post mortem samples.
Turn Around	7 days
Send to	Leeds General Infirmary Clinical Immunology Old Medical School Great George Street Leeds LS1 3EX
Collection Con	Sample 1: As soon as possible after, or within one hour or, onset of reation. Sample 2: 3-6 h post-reation (peak reaction time) Sample 3: 24h post-reation (baseline). Samples should be taken as near as possible to these times after the suspected ana Please contact the Immunology Lab 0113 39 23414 (between 08:30 and 17:00) to advise them a sample has been sent.. If sending out of hours, please contact the main lab on 0113 39 26745 to advise them a sample has been sent Instructions for Lab staff: As soon as the sample arrives in reception centrifuge and store serum in the freezer.
Frequency	Daily
Sample REQ	Blood
Units	ng/mL
IP Acute TAT	- Contact Laboratory
IP Routine TAT	7 days
GP Acute TAT	- Contact Laboratory
GP Routine TAT	7 days
Telepath	TRYA2L
ICE Codes	ITRYA