Voltage gated calcium channel (VGCC) antibodies
This assay detects autoantibodies to P/Q-type (a1A) voltage gated calcium channels for the investigation of Lambert-Eaton myasthenic syndrome (LEMS).
| Tube | Serum Gel |
|---|---|
| ID | 12796 |
| Additional Information | About half of patients with Lambert-Eaton myasthenic syndrome (LEMS) have small cell lung cancer (SCLC) and 85% have voltage gated calcium channel antibodies. However, VGCC antibodies can also be found at low levels in some patients with lung cancer without LEMS. |
| Turn Around | Refer to https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/calcium-channel-antibodies for turn around times, allowing an additional 10 working days for sample processing and reporting |
| Send to | Samples should be sent to the Clinical Immunology laboratory at Old Medical School LGI, who will refer to appropriate referral lab (Oxford) |
| Contact | https://www.leedsth.nhs.uk/a-z-of-services/pathology/specialist-laboratory-medicine-slm/immunology-laboratory/ |
| Advice | https://www.leedsth.nhs.uk/a-z-of-services/pathology/specialist-laboratory-medicine-slm/immunology-laboratory/ |
| Collection Con | No restrictions |
| Frequency | Referred to external laboratory |
| Sample REQ | Blood |
| Ref. Range (Male) | <45 pM = negative |
| Ref. Range (Female) | <45 pM = negative |
| Ref. Range (Paed) | <45 pM = negative |
| Units | pM |
| IP Acute TAT | See https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/calcium-channel-antibodies |
| IP Routine TAT | See https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/calcium-channel-antibodies |
| GP Acute TAT | See https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/calcium-channel-antibodies |
| GP Routine TAT | See https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/calcium-channel-antibodies |
| Telepath | VGCC1L |
| ICE Codes | IVGCC |
