Voltage gated potassium channel (VGKC) antibodies
This assay detects autoantibodies to the voltage-gated potassium channel complex antibody. Voltage gated potassium channel (VGKC) antibodies are found in some cases of acquired neuromyotonia, Morvan's syndrome and voltage-gated potassium channel antibody-related limbic encephalitis
| Tube | Serum Gel |
|---|---|
| ID | 12797 |
| Additional Information | The anti-VGKC Ab assay has the capacity to recognise several proteins making up or associated with the voltage-gated potassium channel. The most common anti-VGKC Ab targets discovered so far are LGI1 and CASPR2, however these do not fully represent the positive anti-VGKC Ab samples tested to date. |
| Turn Around | See https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/potassium-channel-antibodies.aspx for TAT allowing an additional 10 working days for sample processing and reporting |
| Send to | Samples should be sent to the department of Clinical Immunology at LGI who will refer to appropriate referral lab (Oxford) |
| Contact | https://www.leedsth.nhs.uk/a-z-of-services/pathology/specialist-laboratory-medicine-slm/immunology-laboratory/ |
| Advice | https://www.leedsth.nhs.uk/a-z-of-services/pathology/specialist-laboratory-medicine-slm/immunology-laboratory/ |
| Collection Con | No restrictions |
| Frequency | Referred to external laboratory |
| Sample REQ | Blood |
| Ref. Range (Male) | <69pmol/L Negative; 70-130pmol/L = Equivocal; >130pmol/L Positive |
| Ref. Range (Female) | <69pmol/L Negative; 70-130pmol/L = Equivocal; >130pmol/L Positive |
| Ref. Range (Paed) | <69pmol/L Negative; 70-130pmol/L = Equivocal; >130pmol/L Positive |
| Units | pmol/L |
| IP Acute TAT | See https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/potassium-channel-antibodies.aspx |
| IP Routine TAT | See https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/potassium-channel-antibodies.aspx |
| GP Acute TAT | See https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/potassium-channel-antibodies.aspx |
| GP Routine TAT | See https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/potassium-channel-antibodies.aspx |
| Telepath | VGKC1L |
| ICE Codes | IVGKC |
