ADAMTS13 Assay
ADAMTS13 cleaves Von Willebrands factor into smaller multimers. A deficiency of inhibition of ADAMTS13 activity leads to very large Von Willebrands multimers being released into the circulation. These activate platelets causing aggregation and the formation of micro-thrombi. The poor prognosis associated with TTP requires early, accurate diagnosis.
| Tube | 05 (CP) - Citrate |
|---|---|
| ID | 12725 |
| Availability | Weekdays |
| Additional Information | Also known as Von Willebrands cleaving protease. Test is performed at Royal Hallamshire Hospital, Sheffield. |
| Send to | Specialist Coagulation Chancellor / Lincoln Wing Link Corridor Pathology Block 32 St James University Hospital Beckett Street Leeds LS9 7TF |
| Contact | https://www.leedsth.nhs.uk/a-z-of-services/pathology-2/specialist-laboratory-medicine-slm/specialist-coagulation/?stage=Stage |
| Collection Con | 2 x Citrate tube filled to line please |
| Sample REQ | Blood |
| Ref. Range (Male) | 52 - 149 |
| Ref. Range (Female) | 52 - 149 |
| Ref. Range (Paed) | 52 - 149 |
| Units | iu/dL |
| IP Acute TAT | 24 hours |
| IP Routine TAT | 5 days |
| GP Acute TAT | Contact Laboratory |
| GP Routine TAT | 14 days |
| Telepath | ATS13H |
| ICE Codes | LATS13 |
