Hydroxyprogesterone (17-hydroxyprogesterone, 17-OHP)
Used in the investigation of ambiguous genitalia in the newborn infant, diagnosis and monitoring of patients with classical and late-onset congenital adrenal hyperplasia (CAH). 17OH-progesterone should not be requested in infants less than 48 hours old.
| Tube | Serum Gel |
|---|---|
| ID | 12605 |
| Availability | Twice Weekly |
| Additional Information | Urgent assays by arrangement ext 67043, 64717. Investigation of ambiguous genitalia in the newborn, diagnosis and monitoring of CAH patients. 17OHP is raised in CAH due to 21-hydroxylase deficiency. 21-hydroxylase deficiency is the commonest cause of CAH. Elevated concentrations of 17OHP may be seen in sick individuals as part of the stress response. Although appropriate therapy should always be initiated, confirmatory tests for CAH must be performed afterwards. Monitoring patients is difficult due to intrinsic diurnal rhythms in 17OHP, episodic nature of secretion, and the timing of sample collection in relation to glucocorticoid dose. Daily profiles using several samples during the day may offer a more complete picture of therapeutic control (early morning, mid-day, mid-afternoon and evening). This can be done with either blood or saliva (see saliva entry). |
| Turn Around | 14 days |
| Send to | Specialist Laboratory Medicine Block 46 St James hospital Beckett Street Leeds LS9 7TF |
| Contact | 1132067043 |
| Advice | 01132064717, stephen.gibbons@nhs.net |
| Collection Con | No restrictions |
| Sample REQ | Blood |
| Ref. Range (Male) | Adult (> 16y M+F): <5.0 |
| Ref. Range (Female) | Adult (> 16y M+F): <5.0 |
| Ref. Range (Paed) | Neonates (>48h after birth) 5d: <3.0. < 16y M+F : <4.0 |
| Ref. Range Notes | Adult female results may be higher in luteal phase of menstrual cycle |
| Units | nmol/L |
| IP Acute TAT | Contact laboratory |
| IP Routine TAT | 14 days |
| GP Acute TAT | 14 days |
| GP Routine TAT | 14 days |
| Telepath | OHP2J |
| ICE Codes | c |
