Advice after Mitomycin-C instillations

What symptoms to expect after treatment

• Pain and burning sensation when passing urine
• Needing to pass urine more than normal
• You may notice that you pass small amounts of blood in your urine within 24 -48 hours.

What you can do to reduce the severity of side-effects

• Increase your fluid intake avoiding alcohol, fizzy, acidic juices and caffeinated drinks.
• Try some paracetamol / ibuprofen if not allergic.

There is a small risk with Mitomycin treatment; you may notice a rash on the soles of your feet and/or the palms of your hands or the trunk of your body. It may be a sensitivity (allergic) reaction, but if it happens, it is most likely to occur during your first treatment, contact the CNS team for advice.

It is important to avoid getting Mitomycin-C in contact with your skin, so please wash your hands and genitalia (male/female reproductive organs) with soap and water immediately after passing the drug into the toilet. If the solution does get on your skin it may cause a slight rash. If you wash it off immediately with warm, soapy water, it will not harm your skin.

To prevent irritation for yourself or your partner, it is best not to have sexual intercourse for at least 24 hours after each treatment with Mitomycin-C.

We do not recommend getting pregnant or fathering children during and for six months after Mitomycin-C treatment, so it is essential adequate contraceptive measures are used. If you are considering pregnancy or fathering children please discuss this further with your doctor or nurse specialist.

For urgent enquiries

Important

If your closest hospital is not St James’s you may be advised to attend your local hospital emergency department for urgent attention. Please ensure on arrival you show the leaflet LN004675 Advice following Mitomycin-C instillation) so they are aware of the treatment you have had.