ADAMTS13 cleaves Von Willebrands factor into smaller multimers. A deficiency of inhibition of ADAMTS13 activity leads to very large Von Willebrands multimers being released into the circulation. These activate platelets causing aggregation and the formation of micro-thrombi. The poor prognosis associated with TTP requires early, accurate diagnosis.
Tube
05 (CP) – Citrate
ID
12725
Availability
Weekdays
Additional Information
Also known as Von Willebrands cleaving protease. Test is performed at Royal Hallamshire Hospital, Sheffield.
Send to
Specialist Coagulation
Chancellor / Lincoln Wing Link Corridor
Pathology
Block 32
St James University Hospital
Beckett Street
Leeds
LS9 7TF
Contact
Collection Con
2 x Citrate tube filled to line please
Sample REQ
Blood
Ref. Range (Male)
52 to 149
Ref. Range (Female)
52 to 149
Ref. Range (Paed)
52 to 149
Units
iu/dL
IP Acute TAT
24 hours
IP Routine TAT
5 days
GP Acute TAT
Contact Laboratory
GP Routine TAT
14 days