Measurement of alpha-1 antitrypsin is useful in the investigation of emphysema and unexplained liver disease in adults. In paediatric practice, alpha-1 antitrypsin deficiency may be associated with neonatal jaundice.
NOTE: Inflammatory conditions may mask deficiency as AAT is an acute phase reactant. Increased levels also occur in malignancy, pregnancy and those taking exogenous oestrogens.
Tube
Serum Gel
ID
12749
Availability
Weekdays
Additional Information
Deficiency leads to chronic obstructive airways disease, emphysema, neonatal/juvenile liver disease. Samples with an AAT concentration of 0.9g/L or below will undergo phenotypic analysis by isoelectric focusing to determine if the patient has one or more (heterozygosity or homozygosity) AAT deficiency alleles.
Users will be asked to contact the lab if alpha1-antitrypsin levels are borderline to clarify if phenotyping is required. Note, AAT levels may be within normal range in paediatric patients, therefore if there is a strong suspicion of AAT deficiency AAT phenotyping should also be performed.
Turn Around
7 days
Send to
Clinical Immunology
Floor E, Old Medical School, LGI
Great George Street
Leeds
LS1 3EX
Contact and advice
Collection Con
No restrictions
If result is low the Immunology laboratory will add phenotyping test
Frequency
Daily
Sample REQ
Blood
Ref. Range (Male)
1.1 to 2.1 (Adult)
Ref. Range (Female)
1.1 to 2.1 (Adult)
Ref. Range (Paed)
See notes
Ref. Range Notes
Day 1 to 26 weeks = 0.9 to 2.2
26 weeks to 1 years = 0.8 to 1.8
1 years to 5 years= 1.1 to 2
5 years to 10 years = 1.1 to 2.2
10 years to 15 years = 1.4 to 2.3
15 years to adult= 1.2 to 2
Units
g/L
IP Acute TAT
7 days
IP Routine TAT
7 days
GP Acute TAT
7 days
GP Routine TAT
7 days