Also see Alpha-1 Antitrypsin (AAT) and AAT phenotyping. Measurement of alpha-1 antitrypsin is useful in the investigation of emphysema and unexplained liver disease in adults. In paediatric practice, alpha-1 antitrypsin deficiency may be associated with neonatal jaundice.
Tube
EDTA
ID
12798
Availability
Weekdays
Additional Information
Alpha1-Antitrypsin phenotyping is used as a first-line test to identify deficiency. Genotyping is only indicated when a deficiency phenotype has been identified. Phenotyping is used as a first-line test to identify deficiency. AAT genotyping can be used for the confirmation of the AAT phenotype. The genotyping method will identify the Pi*Z and Pi*S gene products but assumes all non-S and non-Z are Pi*M.
Turn Around
See UK NEQAS for turn around time, allowing an additional 10 working days for sample processing and reporting
Send to
Samples should be sent to the department of Clinical Immunology at LGI who will refer to appropriate referral lab (Sheffield PRU)
Contact and advice
Collection Con
No restrictions
Frequency
Referred to external laboratory
Sample REQ
Blood
Ref. Range Notes
See reference range on referral website
Units
NA
IP Acute TAT
See UK NEQAS
IP Routine TAT
See UK NEQAS
GP Acute TAT
See UK NEQAS
GP Routine TAT
See UK NEQAS