Immunochemical levels C1 esterase inhibitor are assessed along with complement C3 and C4. If results indicate, a functional assay will be performed with an appropriate sample.
Tube
Serum Gel
ID
12757
Availability
Weekdays.
Additional Information
Indicated in the investigation of anginoneurotic / hereditary/ acquired angioedema. Recurrent episodes of nonpruritic, non pitting, subcutaneous or submucosal oedema typically involving the arms, legs, hands, feet, bowels, genitalia, trunk, face, tongue, or larynx. C1 esterase inhibitor deficiency is transmitted as an autosomal dominant disorder resulting in Hereditary Angioedema (HAE). A rare, acquired form (AAE) may occur with lymphoproliferative disease and Autoimmune disorders. Two inherited forms exist: in classic Type 1 deficiency C1 esterase levels are low whereas in the less common Type 2 deficiency C1 esterase is produced but is not functional. Samples collected during an acute attack of angioedema due to C1 inhibitor deficiency have a very low C4 level and thus a normal C4 virtually excludes the condition.
Turn Around
Due to extended service pressures please note our TAT have been temporarily extended by 6 weeks beyond the times stated above/below. Please do not contact the lab before this time frame unless there is a clinically urgent need.
Send to
Leeds General Infirmary
Clinical Immunology
Old Medical School
Great George Street
Leeds
LS1 3EX
Collection Con
No restrictions however the functional assay requires a serum sample frozen within one hour of collection.
Frequency
Daily.
Sample REQ
Blood.
Ref. Range (Male)
0.15 to 0.35
Ref. Range (Female)
0.15 to 0.35
Ref. Range (Paed)
0.15 to 0.35
Units
g/L
IP Acute TAT
Contact Laboratory
IP Routine TAT
Due to extended service pressures please note our TAT have been temporarily extended by 6 weeks beyond the times stated above/below. Please do not contact the lab before this time frame unless there is a clinically urgent need.
GP Acute TAT
Contact Laboratory.
GP Routine TAT
Contact Laboratory.