Primary component of classical complement pathway. C1q levels are usually only measured in cases where CH50 is absent or the patient has an increased susceptibility to infection, with the excception of the identification of acquired angioedema. C1q deficiency is rare and associated with SLE and recurrent bacterial infections. In suspected deficiency haemolytic complement should be analysed first. C1q is useful in the differential diagnosis of Aquired Angioedema (AAE).
Tube
Serum Gel
ID
12817
Availability
Weekdays
Additional Information
A deficiency of C1q can lead to a reduced or absent CH50 value. Levels are also low in aquired C1 inhibitor deficiency and reduced in urticarial vasculitis. The sample must be frozen within 2h of collection. Please inform the laboratory prior to collecting the sample.
Turn Around
Refer to relevant laboratory for up to date turn around times, allowing an additional 10 working days for samples processing, dispatch and reporting and validation of the results (estimated 28 days).
Send to
Samples should be sent to the department of Clinical Immunology at LGI who will refer to appropriate referral lab (Sheffield PRU).
Collection Con
The sample must be frozen within 2h of collection. Please inform the laboratory prior to collecting the sample.
Frequency
Referred to external laboratory.
Sample REQ
Blood.
Ref. Range Notes
See reference range on referral website.
Units
mg/L
IP Acute TAT
Contact Laboratory.
IP Routine TAT
7 days.
GP Acute TAT
Contact Laboratory.
GP Routine TAT
7 days.