These tests measure the functional integrity of the classical (CH100) and alternative (AP100) complement pathways. Indicated in suspected complement deficiency eg recurrent infections, especially meningococcal (meningitis) infection.
Tube
Serum Gel
ID
12826
Availability
Weekdays
Additional information
Investigations for complement deficiency will only be undertaken upon request (direct or indirect) from consultant immunologists.
Complement deficiencies should be investigated using a cascade of tests:
Measurement of haemolytic activity (CH100/AP100) and immunochemical measurement of C3 and C4.
If impaired activity is detected, immunochemical detection of individual components may be undertaken, following consultation with the Clinical Immunologists. If the functional complement tests are normal, testing for individual complement components is rarely needed. If these tests are performed too soon after acute infection the results may be falsely low.
Turn around
30 days
Send to
Leeds General Infirmary
Clinical Immunology
Old Medical School
Great George Street
Leeds
LS1 3EX
Collection Con
The sample must be received and frozen within one hour of collection to maintain sample integrity for this functional assay. Please inform the laboratory prior to requesting this test (23540).
Frequency
Monthly
Sample REQ
Blood
Ref. Range (Male)
See Reference range note
Ref. Range (Female)
See Reference range note
Ref. Range (Paed)
See Reference range note
Ref. Range Notes
CH100 392 – 1019 U/mL AP100 75 – 125 %normal reference serum (nrs)
Units
Not defined
IP Acute TAT
Contact Laboratory
IP Routine TAT
30 days
GP Acute TAT
Not available
GP Routine TAT
Not available