Gabapentin is useful in partial seizures: simple, complex or partial with secondary generalised tonic-clonic seizures. The mechanism of action is unknown but may be through release of GABA. It has also been used in migraine and in chronic pain relief. Misuse potential is high and it is readily available from illicit sources.
Additional information
For therapeutic monitoring purposes, a trough (before dose) sample should be taken.
If toxicity is suspected, take sample at time patient is symptomatic.
Therapeutic drug monitoring is not recommended due to wide range of clinically effective serum concentrations and a low incidence of toxicity. However, blood measurement may be used to adjust dosing during renal failure or to assess compliance.
Turn around
Turnaround time stated by referral laboratory: 5 working days
Collection Con
Minimum volume: 50 uL
Instructions to lab: Centrifuge sample, separate serum and store in fridge.
Sample type
Blood
Reference Range
2 – 20 mg/L