Lupus anticoagulant is a heterogenous group of autoantibodies, usually directed at phospholipids. The presence of lupus anticoagulants is generally accompanied by a raised APTT but the physiological effect is an increase in the risk of thrombosis. A Lupus anticoagulant screen consists of a coagulation screen including a second APTT reagent, Actin FS APTT and a Russell’s viper venom ratio.
Tube
05 (CP) – Citrate
ID
29867
Availability
Weekdays
Additional information
Testing CANNOT be performed if: 1). The patient is on unfractionated heparin. All positive screens require repeat in 12 weeks to demonstrate continuity. 2) DOACs – Dabigatran, Rivaroxaban and Apixaban may also influence LA.
Turn around
7 days
Send to
xSpecialist Coagulation
Chancellor / Lincoln Wing Link Corridor
Pathology
Block 32
St James University Hospital
Beckett Street
Leeds
LS9 7TF
Contact
[LINK to specialist coagulation]
Collection Con
2 x citrate samples (all citrate tubes must be filled to the line).
Samples must be processed within 6 hours of being taken.
Plasma samples must be double-spun to remove platelets.
Sample REQ
2 x citrate samples (all citrate tubes must be filled to the line).
Samples must be processed within 6 hours of being taken.
Plasma samples must be double-spun to remove platelets.
Ref. Range Notes
Results will be reported with numerical values for each assay and an interpretative comment.
Units
Positive/Negative