Idiopathic inflammatory myopahies are an inflammatory disease of skeletal muscles. These myopathies can be divided into polymyositis, dermatomyositis, idiopathic myositis, anti-synthetase syndrome and overlap syndrome.
Tube
Serum Gel
ID
12789
Additional Information
This assay detects autoantibodies to 11 different myositis associated antigens: Jo-1, Mi-2alpha and Mi-2beta, TIF1gamma (transcriptional intermediary factor), MDA5 (melanoma differentiation-associated gene 5), XNP2, SAE (SAE1/2), Ku, PM-Scl100, PM-Scl75, SRP (signal recognition particle), PL-7, PL-12, EJ. OJ and Ro-52. Anti-Jo-1 Ab are found in polymyositis, often occur simultaneously in autoimmune diseases such as SLE, systemic sclerosis or interstitial lung fibrosis. Mi-2 Ab are highly specific for dermatomyositis. Anti- Jo-1, PL-7, PL-12 EJ and OJ antibodies are associated with anti-synthetase syndrome. Anti-SRP Ab is a marker for immune-mediated necrotising myopathy. Anti-PM-Scl 75 and 100 Ab are associated with overlap syndrome which manifests as a combination of polymyositis, dermatomyoitis and systemic sclerosis symptoms. Anti-Ro52 Ab are not associated with a specific disease, but can be found in both autoimmune and infectious diseases.
Send to
Leeds General Infirmary
Clinical Immunology
Old Medical School
Great George Street
Leeds
LS1 3EX
Frequency
Every fortnight
Sample REQ
Blood
Ref. Range (Male)
N/A – Interpretive
Ref. Range (Female)
N/A – Interpretive
Ref. Range (Paed)
N/A – Interpretive
Ref. Range Notes
Positive/Negative
Units
N/A
IP Acute TAT
Contact Laboratory
IP Routine TAT
14 days
GP Acute TAT
Contact Laboratory
GP Routine TAT
14 days