PIIINP can be a marker of hepatic fibrosis. Used to monitor hepatic fibrosis, particularly in dermatology patients receiving methotrexate. Part of ELF testing.
Tube
01 (SE) – Serum Gel
ID
Tests&Tubes0098
Additional Information
PIIINP is the amino terminal peptide of type III procollagen, released from the precursor peptide during the synthesis and deposition of type III collagen. PIIINP in the serum can be derived from the synthesis of new type III collagen or from the degradation of existing type III collagen fibrils. There is evidence that serum PIIINP measurement is an effective non-invasive test for the detection and monitoring of methotrexate-induced liver fibrosis and cirrhosis, and serial measurements may reduce the need for liver biopsy. Dermatology patients with repeated normal levels of PIIINP are very unlikely to have significant liver damage from fibrosis or cirrhosis. The role of PIIINP in rheumatology patients is unclear as it can be falsely elevated in inflammatory arthritis.
Turn Around
A&E: N/A
Day Case: 24 Hours
In-Patient: 24 Hours
Out-Patient: 24 Hours
GP: N/A
Send to
Blood Sciences LGI
Contact
For further details please contact Leeds Pathology customer services: [email protected].
Advice
Collection Con
Minimum volume – 250µl serum / plasma
Instructions for Lab Staff: Standard lab processing- No special requirements.
Sample REQ
Blood.
Ref. Range Notes
Units
µg/L