This test detects the present of serum immunoglobulin kappa and lambda free light chains, and expresses these as a ratio, the sFLC ratio.
Tube
Serum Gel
ID
12811
Availability
Weekdays
Additional Information
Measurement of the kappa:lambda ratio provides a numerical indicator of clonality (Tumours produce monoclonal excess of only one of the light chain types, often with bone marrow suppression of the alternative light chain, so that the kappa:lambda ratios becomes skewed). A patient with a ‘kappa’ paraprotein (eg IgG Kappa, Kappa LCMM) will have an increased serum free ligh chain kappa:lambda ratio. A patient with a ‘lambda’ paraprotein with have a decreased serum free light chain kappa:lambda ratio.
Turn Around
7 days
Send to
Leeds General Infirmary
Clinical Immunology
Old Medical School
Great George Street
Leeds
LS1 3EX
Collection Con
No restrictions.
Frequency
Daily.
Sample REQ
Blood.
Ref. Range (Male)
As set by Siemens N latext sFLC assay: Free kappa: 6.7 to 22.4 Free Lambda: 8.3 to 27 Kappa:Lambda Ratio: 0.31 to 1.56
Ref. Range (Female)
As set by Siemens N latext sFLC assay: Free kappa: 6.7 to 22.4 Free Lambda: 8.3 to 27 Kappa:Lambda Ratio: 0.31 to 1.56
Ref. Range (Paed)
As set by Siemens N latext sFLC assay: Free kappa: 6.7 to 22.4 Free Lambda: 8.3 to 27 Kappa:Lambda Ratio: 0.31 to 1.56
Ref. Range Notes
(The sFLC kappa:lambda ratio in patients with renal failure do not differ from the reference limits for healthy controls).
Units
mg/L
IP Acute TAT
Contact Laboratory
IP Routine TAT
7 days
GP Acute TAT
Contact Laboratory
GP Routine TAT
7 days