Scleroderma (systemic sclerosis) is a complex disease associated with extensive fibrosis, vascular alterations and autoantibodies against various cellular antigens. There are two major subgroups: limited cutaneous scleroderma (lcSSc) (skin involvement limited to distal extremities) and diffuse cutaneous scleroderma (dcSSc) (symptoms diffusely distributed over trunk, distal and proximal extremities and the face). Scleroderma can also lead to dysfunction/failure of internal organs.
Tube
Serum Gel
ID
12793
Availability
Weekdays
Additional Information
This assay detects autoantibodies to 13 different scleroderma associated antigens: Scl-70, CENP A, CENP B, RP11 and RP155 (RNA polymerase III subunits), Fibrillarin, NOR90, Th/To, PM-Scl 100, PM-Scl 75, Ku, PDGFR (Platelet derived growth factor receptor) . Anti-Scl-70 Ab can be detected in up to 65% of patients with dcSSc. Anti-centromere Ab are most commonly associated with lcSSc and are detected in up to 82% of these patients. PM-Scl 100 and 75 Ab can be found on SSc and dermato-/polymyositis. The other autoantibodies are less prevalent in SSc. Anti-Ro52 Ab are not associated with a specific disease, but can be found in both autoimmune and infectious diseases.
Turn Around
Due to extended service pressures please note our TAT have been temporarily extended by 6 weeks beyond the times stated above/below. Please do not contact the lab before this time frame unless there is a clinically urgent need.
Send to
Leeds General Infirmary
Clinical Immunology
Old Medical School
Great George Street
Leeds
LS1 3EX
Frequency
Every fortnight
Collection Con
Available only after discussion with a Consultant Immunologist
Sample REQ
Blood
Ref. Range (Male)
NA Interpretive
Ref. Range (Female)
NA Interpretive
Ref. Range (Paed)
NA Interpretive
Ref. Range Notes
Positive/Negative
Units
NA
IP Acute TAT
Contact Laboratory
IP Routine TAT
Due to extended service pressures please note our TAT have been temporarily extended by 6 weeks beyond the times stated above/below. Please do not contact the lab before this time frame unless there is a clinically urgent need.
GP Acute TAT
Contact Laboratory
GP Routine TAT
Due to extended service pressures please note our TAT have been temporarily extended by 6 weeks beyond the times stated above/below. Please do not contact the lab before this time frame unless there is a clinically urgent need.