Topiramate is an anticonvulsant drug. It is rapidly and efficiently absorbed from the GI tract after which it is eliminated, predominantly unchanged, via the renal route with a plasma half life of 20-30 hrs. A proportion of the drug undergoes hepatic metabolism by oxidative pathways and the clearance is increased by enzyme inducing drugs. Clinical indication for measuring: Therapeutic drug monitoring (TDM) when modifying treatment or to establish baseline values. Also to check compliance or if toxicity is suspected.
Tube
04 (EP) – EDTA Plasma
ID
Tests&Tubes0247
Additional Information
Since large inter-individual differences exist between the dose required to achieve safe and effective plasma concentrations, and topiramate is often prescribed together with other AED’s which have similar CNS side-effects, the measurement of serum or plasma topiramate levels is a valuable aid to individualisation of treatment.
Turn Around
Turnaround time stated by Cardiff toxicology lab: 7 days
Send to
Blood Sciences LGI
(Test referred to: Cardiff toxicology lab)
Contact
For further details please contact Leeds Pathology customer services: [email protected].
Advice
Full information on all referred tests can be found on the referred tests information database, EQMS reference BSF2REC17003.
Collection Con
Instructions to lab: Centrifuge sample, separate plasma and store frozen. Serum gel tubes are not suitable.
Minimum volume: 1 mL plasma.
Sample REQ
Blood
Ref. Range Notes
5 to 20mg/L
Units
mg/L