Open Clinical Trials
Here you will find a list of all of the current Open Clinical Trials that we are running within the Stroke Research Team. Should you wish to find out any more pieces of information about the trials, please send an email and we will answer your query.
| Trial short title |
ATTEST-2 |
| Trial long title |
Alteplase-Tenecteplase trial evaluation for stroke thrombolysis |
| Trial outcome |
To compare the safety and efficacy of Tenecteplase with Alteplase for thrombolysis in acute ischaemic stroke |
| Chief investigator |
Prof. Keith Muir |
| Principle investigator |
Dr. Ahamad Hassan |
| Start date |
12/12/2016 |
| Project type |
Non-Commercial |
| Trial short title |
BRAINS |
| Trial long title |
British Repository of DNA in Stroke |
| Trial outcome |
To establish a Caucasian and South Asian Stroke DNA repository |
| Chief investigator |
Dr. Pankaj Sharma |
| Principle investigator |
Dr. Ahamad Hassan |
| Start date |
02/04/2007 |
| Project type |
Non-Commercial |
| Trial short title |
DNA LACUNAR-2 |
| Trial long title |
Genetic Risk Factors for Cerebral Small Vessel Disease |
| Trial outcome |
Can genetic risk factors underlying MRI-defined lacunar stroke be identified using the traditional GWAS approach, and can we increase the ability to detect novel genetic variants by leveraging disease heterogeneity? |
| Chief investigator |
Prof. Hugh Markus |
| Principle investigator |
Dr. Ahamad Hassan |
| Start date |
11/08/2016 |
| Project type |
Non-Commercial |
| Trial short title |
ECST-2 |
| Trial long title |
The 2nd European Carotid Surgery Trial |
| Trial outcome |
An international randomised trial investigating the optimal treatment of patients with symptomatic or asymptomatic moderate or severe carotid stenosis at low or intermediate risk of future stroke. |
| Chief investigator |
Prof. Martin Brown |
| Principle investigator |
Dr. Marc Randall |
| Start date |
23/03/2012 |
| Project type |
Non-Commercial |
| Trial short title |
FAMILIAL |
| Trial long title |
A UK Familial Cerebral Small Vessel Disease Study |
| Trial outcome |
To perform a longitudinal prospective study of patients with familial SVD, both due to known genes causing monogenic SVD, and also cases with Mendelian inheritance in which the underlying genes have not yet been identified. |
| Chief investigator |
Prof. Hugh Markus |
| Principle investigator |
Dr. Ahamad Hassan |
| Start date |
24/06/2016 |
| Project type |
Non-Commercial |
| Trial short title |
RIGHT-2 |
| Trial long title |
Rapid Intervention With Glyceryl Trinitrate in Hypertensive Stroke Trial-2 |
| Trial outcome |
Assessment of safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor, and of the feasibility of a multicentre ambulance-based stroke trial |
| Chief investigator |
Prof. Philip Bath |
| Principle investigator |
Dr. Ahamad Hassan |
| Start date |
25/09/2015 |
| Project type |
Non-Commercial |
| Trial short title |
RESTART |
| Trial long title |
Restart or Stop Antithrombotics Ramdomised Trial |
| Trial outcome |
Testing whether a policy of starting antiplatelet drugs (one or more of aspirin, clopidogrel, or dipyridamole, chosen at investigator's discretion) results in a beneficial net reduction of all serious vascular events over two years compared with a policy of avoiding antiplatelet drugs. |
| Chief investigator |
Prof. Rustam Al-Shahi Salman |
| Principle investigator |
Dr. Ahamad Hassan |
| Start date |
01/05/2013 |
| Project type |
Non-Commercial |
| Trial short title |
XILO-FIST |
| Trial long title |
Xanthine Oxidase Inhibition for Improvement of Long-term Outcomes Following Ischaemic Stroke and Transient Ischaemic Attack |
| Trial outcome |
To evaluate the effect of allopurinol 300 mg twice daily on white matter hyper-intensity (WMH) progression, left ventricular hypertrophy (LVH) and arterial blood pressure (BP) after ischaemic stroke. |
| Chief investigator |
Dr. Jesse Dawson |
| Principle investigator |
Dr. Ahamad Hassan |
| Start date |
18/05/2015 |
| Project type |
Non-Commercial |
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