The Leeds Teaching Hospitals NHS Trust

Upcoming Clinical Trials

Please click on any of the following links below to be taken straight to the clinical trial information.

Trial short title
SoSTART
Trial long title
Stop or start anticoagulants randomised trial
Trial outcome
For adults surviving spontaneous (non-traumatic) symptomatic intracranial haemorrhage with persistent/paroxysmal atrial fibrillation/flutter (AF), does starting full treatment dose oral anticoagulation (OAC) result in a beneficial net reduction of all serious vascular events compared with not starting OAC?
Chief investigator
Prof. Rustam Al-Shahi Salman
Principle investigator
Dr. Vasileios Papavasileiou
Estimated start date
Early 2018
Project type
Non-Commercial
More information
https://www.ed.ac.uk/usher/edinburgh-clinical-trials/our-studies/all-current-studies/sostart
Trial short title
LACI-2
Trial long title
Lacunar Intervention Trial 2: Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to prevent recurrent lacunar stroke and progression of cerebral small vessel disease
Trial outcome
The trial hypothesis is to test whether a much larger scale study testing the effects of Cilostazol and ISMN on preventing brain damage from small vessel disease will be feasible. We will assess how easy is it to identify suitable patients, how many of them are willing to take part in the study and how many stay on the study for the full 12 months. Feedback from participants on study procedures/burden will also inform any future studies. We will also collect information on how many patients have another stroke, experience difficulties in independent daily living or in thinking skills, and on drug safety such as bleeding.
Chief investigator
Prof. Joanna Wardlaw
Principle investigator
Dr. Ahamad Hassan
Estimated start date
Early 2018
Project type
Non-Commercial
More information
https://www.ed.ac.uk/usher/edinburgh-clinical-trials/our-studies/ukcrc-studies/laci
Trial short title
PRECIOUS
Trial long title
Prevention of complications to improve outcome in elderly patients with acute stroke. 
Trial outcome
To assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in elderly patients with acute stroke.
Chief investigator
H. Bart van der Worp MD PhD
Principle investigator
Dr. Vasileios Papavasileiou
Estimated start date
Early 2018
Project type
Non-Commercial
More information
https://www.precious-trial.eu/
Trial short title
SIGNUM
Trial long title
Stroke Investigation Network - Understanding Mechanisms
Trial outcome
SIGNUM is an observational study that will recruit patients from stroke services including TIA clinics, HASU’s, ASU’s, rehabilitation facilities, GP’s and any other service that looks after such patients. We will also include patients who are at risk of stroke for example those with arterio-venous malformations, cavernomas or extra cranial vessel abnormalities. The main focus of which is on collecting genetic and biomarker data linked to data recorded as part a patient’s routine care, using the paper or electronic health record, however numerous projects are expected to emerge from the network.  This model will enable the research to be embedded into routine clinical care, with the aim of being cost effective and time efficient.  The longitudinal component of collecting functional outcomes will be embedded into routine follow up clinics, and where necessary supplemented by linking with GP records and/or postal/telephone/web based or routine and research clinic contact. Links to electronic health databases (HES, SSNAP, and CPRD, MINAP and similar data / disease registries) and routine clinical follow ups within clinical stroke services themselves will facilitate collection of hard endpoints of morbidity and mortality, disease specific endpoints and endpoints that may represent adverse reactions to medications used for the treatment and/ or prevention of stroke.
Chief investigator
TBC
Principle investigator
TBC
Estimated start date
Early 2018
Project type
Non-Commercial
More Information
https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/determinants-of-prognosis-in-stroke/