Cholinesterase activity/phenotype/genotype
Cholinesterase deficiency will result in prolonged paralysis after the use of muscle relaxants for surgery. Indications for requesting: prediction of susceptibility to prolonged apnoea after administration of suxamethonium or mivacurium, scoline apnoea, family studies of patients with cholinesterase deficiency, pesticide workers.
| Tube | 03 (EB) - EDTA Blood |
|---|---|
| ID | Tests&Tubes0168 |
| Additional Information | Please contact the Duty Biochemist if this test is required: 0113 39 26922 option 2. Samples should not be collected less than 12h after the administration of suxamethonium or mivacurium. If patient has been treated with fresh frozen plasma or a cholinesterase preparation, a period of at least 6 weeks should be allowed before a sample is collected. Sample should not be taken during a suspected episode of suxamethonium prolonged apnoea, take once awake and breathing unaided. |
| Turn Around | Turnaround time stated by Bristol Southmead Hospital: Activity 1 week Phenotyping 3 weeks Genotyping 10 weeks |
| Send to | Blood Sciences LGI (Test referred to: Bristol Southmead Hospital.) |
| Contact | For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net. |
| Advice | Full information on all referred tests can be found on the referred tests information database, EQMS reference BSF2REC17003. |
| Collection Con | Instructions to lab: Do NOT centrifuge. Store whole blood in fridge. Minimum volume: 3 mL whole blood 1 mL serum. |
| Sample REQ | Blood |
| Ref. Range Notes | Activity: > 5300 U/L |
| Units | U/L |
| Telepath | CHE1R & SA1R |
