Orexin (hypocretin)
Investigation of narcolepsy and other neurological sleep disturbances. Orexin (hypocretin) is a neurotransmitter that regulates wakefulness and appetite. The most common form of narcolepsy, in which the sufferer briefly loses muscle tone (cataplexy), is caused by a lack of orexin in the brain.
| Tube | 09 (CSF) - Plain CSF |
|---|---|
| ID | Tests&Tubes0222 |
| Turn Around | Turnaround time stated by Churchill Hospital: 42 working days (8-9 weeks) |
| Send to | Blood Sciences LGI (Test referred to: the Churchill Hospital) Oxford. |
| Contact | For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net. |
| Collection Con | 2 mL CSF required. Instructions to lab: Store in fridge before dispatch. If volume is sufficient, retain a frozen aliquot in the lab for safekeeping. |
| Sample REQ | CSF |
| Ref. Range Notes | Values >200 pg/mL are seen in healthy controls. Values of <110 pg/mL are mainly seen in patients with narcolepsy with cataplexy. Values between 110-200 pg/mL can be seen in patients with other neurological diseases associated with sleep disturbances. |
| Units | pg/mL |
| Telepath | OREX1R & SA1R |
