Procollagen peptide type III (P3NP)
PIIINP can be a marker of hepatic fibrosis. Used to monitor hepatic fibrosis, particularly in dermatology patients receiving methotrexate. Part of ELF testing.
| Tube | 01 (SE) - Serum Gel |
|---|---|
| ID | Tests&Tubes0098 |
| Additional Information | PIIINP is the amino terminal peptide of type III procollagen, released from the precursor peptide during the synthesis and deposition of type III collagen. PIIINP in the serum can be derived from the synthesis of new type III collagen or from the degradation of existing type III collagen fibrils. There is evidence that serum PIIINP measurement is an effective non-invasive test for the detection and monitoring of methotrexate-induced liver fibrosis and cirrhosis, and serial measurements may reduce the need for liver biopsy. Dermatology patients with repeated normal levels of PIIINP are very unlikely to have significant liver damage from fibrosis or cirrhosis. The role of PIIINP in rheumatology patients is unclear as it can be falsely elevated in inflammatory arthritis. |
| Turn Around | A&E: N/A Day Case: 24 Hours In-Patient: 24 Hours Out-Patient: 24 Hours GP: N/A |
| Send to | Blood Sciences LGI |
| Contact | For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net. |
| Collection Con | Minimum volume - 250µl serum / plasma Instructions for Lab Staff: Standard lab processing- No special requirements |
| Sample REQ | Blood |
| Ref. Range Notes | Blood Sciences reference ranges are available through the useful information and links page: https://www.leedsth.nhs.uk/a-z-of-services/pathology/blood-sciences/useful-information-and-links/ |
| Units | µg/L |
| Telepath | P3NP2L |
| ICE Codes | LP3NP |
