The Leeds Teaching Hospitals NHS Trust

Procollagen peptide type III (P3NP)

Procollagen peptide type III (P3NP)

PIIINP can be a marker of hepatic fibrosis. Used to monitor hepatic fibrosis, particularly in dermatology patients receiving methotrexate. Part of ELF testing.

Tube 01 (SE) - Serum Gel
ID Tests&Tubes0098
Additional Information PIIINP is the amino terminal peptide of type III procollagen, released from the precursor peptide during the synthesis and deposition of type III collagen. PIIINP in the serum can be derived from the synthesis of new type III collagen or from the degradation of existing type III collagen fibrils. There is evidence that serum PIIINP measurement is an effective non-invasive test for the detection and monitoring of methotrexate-induced liver fibrosis and cirrhosis, and serial measurements may reduce the need for liver biopsy. Dermatology patients with repeated normal levels of PIIINP are very unlikely to have significant liver damage from fibrosis or cirrhosis. The role of PIIINP in rheumatology patients is unclear as it can be falsely elevated in inflammatory arthritis.
Turn Around A&E: N/A
Day Case: 24 Hours
In-Patient: 24 Hours
Out-Patient: 24 Hours
GP: N/A
Send to Blood Sciences LGI
Contact For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net.
Collection Con Instructions for Lab Staff: Standard lab processing - No special requirements.
Sample REQ Blood
Ref. Range Notes Blood Sciences Refernce ranges available through the useful information and links page:
https://www.leedsth.nhs.uk/a-z-of-services/pathology/blood-sciences/useful-information-and-links/
Units µg/L
Telepath P3NP2L
ICE Codes LP3NP