Functional Complement Activity
These tests measure the functional integrity of the classical (CH100) and alternative (AP100) complement pathways. Indicated in suspected complement deficiency eg recurrent infections, especially meningococcal (meningitis) infection.
| Tube | Serum Gel |
|---|---|
| ID | 12826 |
| Availability | Weekdays |
| Additional Information | Investigations for complement deficiency will only be undertaken upon request (direct or indirect) from consultant immunologists. Complement deficiencies should be investigated using a cascade of tests: Measurement of haemolytic activity (CH100/AP100) and immunochemical measurement of C3 and C4. If impaired activity is detected, immunochemical detection of individual components may be undertaken, follwing consultation with the Clinical Immunologists. If the functional complement tests are normal, testing for individual complement components is rarely needed. If these tests are performed too soon after acute infection the results may be falsely low. |
| Turn Around | 30 days |
| Send to | Leeds General Infirmary Clinical Immunology Old Medical School Great George Street Leeds LS1 3EX |
| Collection Con | The sample must be received and frozen within one hour of collection to maintain sample integrity for this functional assay. Please inform the laboratory prior to requesting this test (23540). |
| Frequency | Monthly |
| Sample REQ | Blood |
| Ref. Range (Male) | See Reference range note |
| Ref. Range (Female) | See Reference range note |
| Ref. Range (Paed) | See Reference range note |
| Ref. Range Notes | CH100 392 - 1019 U/mL AP100 75 - 125 %normal reference serum (nrs) |
| Units | - Not Defined - |
| IP Acute TAT | - Contact Laboratory |
| IP Routine TAT | 30 days |
| GP Acute TAT | Not available |
| GP Routine TAT | Not available |
| Telepath | HCA1L |
| ICE Codes | IHCA |
