The Leeds Teaching Hospitals NHS Trust

Yorkshire and North East Genomic Laboratory Hub, Central Lab


The Yorkshire and North East Genomic Laboratory Hub, Central Lab incorporates Molecular Genetics, Cytogenetics and a Molecular Oncology Diagnostic Facility. The laboratory is supported by the Translational Genomics Unit. The service is based at St James’s Hospital and is part of the Leeds Teaching Hospitals NHS Trust.

What We Do

The laboratory provides genetic analysis for inherited and acquired diseases for the population of Yorkshire. Services are also available nationally, as part of the UK Genetic Testing Network (UKGTN), and on an international basis.
The Laboratory is accredited by UKAS for its established services.

This website is aimed primarily at health workers as an information resource.

Referral Forms

Cytogenetics and Molecular Oncology

Molecular Genetics Referral Forms

Notice to users - coronavirus disease COVID-19 (virus SARS-CoV-2) - impact on genomic/genetic services and sample acceptance

Our current service is significantly affected

  • Sample acceptance
  • We are unable to process samples from patients with confirmed SARS-CoV-2 infection; samples from such patients should only be taken and sent to the laboratory once their COVID-19 symptoms have resolved.
  • Samples from patients with suspected SARS-CoV-2 infection will be held and only processed once there is confirmation of a negative coronavirus test result.
  • Please ensure that any samples taken from patients with known SARS-CoV-2 infection or suspected COVID-19 symptoms are clearly labelled as such.  Failure to do so may place our staff at risk.
  • The following genomic/genetic services will be continue to be prioritised
  • Tests for oncology patients
  • Prenatal diagnostic tests
  • Diagnostic and carrier tests which impact current pregnancies or treatment
  • Urgent newborn diagnostic tests
  • Newborn screening

See the current Service User Letter for further details: COVID-19 Business Continuity Plan

Supplementary advice for "Extremely Vulnerable" patients can be found on the Clinical Genetics site.

Other services may be delayed. Please contact us where there is particular clinical urgency.

Notice to service users

Letter to users: accreditation of DNA extraction facilities reinstated

Laboratory change of name and address

Letter to users: laboratory change of name and address, effective 15th July 2019

Notice to service users

Letter to users: constitutional genetic testing services

Letter to users: somatic cancer genetic testing services

Changes to current service

In response to NHS England’s recent Strategy and Service Specification for the future of Genomics services in England, Newcastle Teaching Hospitals, Leeds Teaching Hospitals, Sheffield Children’s Trust, Sheffield Teaching Hospitals and NewGene have formed the Yorkshire and North East Genomic Laboratory Hub (YNEGLH); an exciting collaboration to provide services for Genomics across Yorkshire and Humber and the North.

The Leeds Genetics Service will continue to receive samples, perform genomic tests and dispatch DNA samples for specialist testing to the appropriate laboratory, as part of YNEGLH. We will issue further information about the future genomic testing arrangements as it becomes available.

NHS England are currently producing the National Genomic Test Directory that will specify which genomic tests are commissioned by the NHS in England, the technology by which they are available, and the patients who will be eligible to access to a test. The final draft 2018/2019 National Genomic Test Directory for rare and inherited disorders and cancer can be accessed at

 Changes to disease services

Letter to users re: changes to microarray service

Letter to users re: changes to Whipple disease service

Letter to users re: change to testing strategy for recurrent miscarriage patients

Change to format of oncology reports

Please note that from 01/01/18 solid tumour and molecular oncology results will be reported and integrated into cellular pathology reports. Separate reports from the Leeds Genetics Lab will no longer be issued.


Contact Us

Cytogenetic Enquiries:
0113 2065419           

Molecular Enquiries:
0113 2065205           

Sample referral address

Yorkshire & North East Genomic Laboratory Hub, Central Lab
Genomic Specimen Reception (Histopathology Department)
Bexley Wing, Level 5
St James’s University Hospital,
Beckett Street,

Opening Hours

Mon - Fri 8:30am - 5:00pm

For more information about our services covered under UKAS accreditation, please see E Schedule 8096

For more information about the scope of our work please visit the British Society for Genetic Medicine website.