Anti-D Prophylaxis

Anti-D immunoglobulin for Rh(D) prophylaxis is available from the Blood bank on each site for any Rh(D) Negative woman who has had a potentially sensitising episode, in accordance with current national guidelines.

• For sensitising episodes up to 20 weeks gestation, 500iu anti-D is administered. A Kleihauer test is not required.
• For sensitising episodes between 20 weeks and term, 1500iu anti-D is administered and a Kleihauer test performed.
• Anti-D prophylaxis is inappropriate for women who have formed immune anti-D.

Routine Antenatal Anti-D Prophylaxis (RAADP)

1500 iu (300mg) Rhophylac anti-D has been offered to all RH(D) Negative pregnant women in the Leeds area (NICE guidelines - 2002) since April 2005. The Rhophylac immunoglobulin is administered i.v. at the 28 week antenatal check held at the LGI & SJUH Antenatal Clinics. Rh(D) negative women should be referred to the relevant clinic via their midwife. The 28 week blood grouping sample should be taken prior to the administration of Rhophylac to prevent interference with the antibody screen.

Please bear in mind that:

• Rh(D) Negative women should still be given a stat dose of anti-D if they have a further sensitising episode.
• Anti-D prophylaxis is inappropriate for women who have formed immune anti-D.