The Leeds Teaching Hospitals NHS Trust

Pathology

Cancer Studies

CaPP3

CaPP3 i.e. Cancer Prevention Project 3 focuses on finding the optimal Aspirin dose of those with a mismatch repair gene defect causing Lynch syndrome.

Participants with Lynch Syndrome are invited to take part in a non-placebo trial getting enteric coated Aspirin tablets. The first two years is blinded , followed by a further three years of 100, 300 or 600mg of Aspirin as randomised.

They will also be part of a national registry which provides careful follow-up to report side effects and provides detailed information about any cancers or polyps found on routine check-ups. For details and more information about the study, visit The Cancer Prevention Project 3 Website.

 COGS2 - Colorectal Cancer Genetic Susceptibility Study 2

It has recently been shown that people with changes in certain genes are more likely to develop various tumours, including bowel cancer.  Not everyone who has a gene change will develop cancer because many factors affect the way a gene works.  In some families where a gene change has been found, there are many relatives who have had cancer and yet in other families there are very few cancers.  This means that the genes not only behave differently among families but are also having a varying effect on individuals within those families.

The COGS2 study is interested in looking at these families to try and help us understand and explain what makes cancer develop in some people and not others.  We hope that this will give us a better understanding of what having a gene change really means. In order to do this the COGS2 researchers are looking for people who, through genetic testing, have been shown to carry a change which gives an increased risk of bowel cancer. Participants will have a blood test taken and will agree to share some of their medical history with the researchers.

CORGI2 - Identification and Characterisation of Inherited Predispositions to colorectal tumours

Malignant bowel tumours, such as cancers, are rather common and benign bowel tumours, such as polyps are very common. Inherited factors (genes) may increase or decrease a person’s risk of bowel tumours.

The CORGI2 study research team are studying patients and families with a history of bowel tumours in order to identify genes that could affect the risk of developing this condition and find out why they have this effect.

Sometimes bowel tumours can occur together with other types of tumours. The  CORGI2 researchers are also studying patients and families who have developed tumours, such as cancers of the uterus (womb), that are potentially related to bowel cancer.

For more information take a look at the HRA Website.

EMBRACE - Epidemiological Study of Familial Breast Cancer

This study collects information about people who have inherited faulty breast cancer genes.

A small number of men and women have inherited faulty genes which means that they are at an increased risk of developing certain cancers. Two of these genes are called BRCA1 and BRCA2. When someone has a fault in these genes they are more likely to develop cancers of the breast, ovary or prostate.

The study aims to create a register of families who have a fault in these genes. The people taking part will be asked to fill in a questionnaire and to give a small sample of blood, which will be looked at in a laboratory. With this information they hope to find out: 

  • How many people go on to develop cancer
  • What other factors may play a part in the development of cancer
  • How the cancer risk may be reduced

The findings of this study will help doctors in the future to decide the best way to manage someone who has these faulty genes.

GENPROS

This study is looking at how faults in the BRCA1 and BRCA2 genes can affect prostate cancer. It is looking at whether the cancer is more or less severe, and whether there are differences in how well the prostate cancer responds to treatment.

To do this the researchers are looking for two groups of men:

  • those who have been diagnosed with prostate cancer and who do have a change in the BRCA1 and BRCA2 genes; and
  • men who have been diagnosed with prostate cancer and who do not have a change in the BRCA1 or BRCA2 genes.

Here are some of the other studies we are recruiting to here at Leeds Clinical Genetics. If any of them sound interesting to you do get in touch with us at clingenresearch@nhs.net

Genetic Mechanisms in Polyposis of the Bowel

SEARCH - A population based study of genetic predispositions and gene - environment interactions in Ovarian Cancer

SCOTTY - Sequencing of Colon Trios in the Young

BOLT - Biomarkers of Lynch Syndrome

HumGenDis - Human Genetic Disease study