The Leeds Teaching Hospitals NHS Trust


Itraconazole Levels

Itraconazole Levels


Confirmation of adequate levels and alerting to toxic levels in patients receiving itraconazole for treatment or prophylaxis of fungal disease.


Drug concentration in mg/L, with advice on target levels.  Levels should be maintained above 0.5 mg/L. If levels are below this: ensure dosing is appropriate in relation to meals - consider increasing dose or examine effects of concomitant medications.


The uncertainty of measurement of this assay has been characterised in the following way, a positive control sample at the approximate level the same as the cutoff for a therapeutic level, ie 0.5mg/L, tested over 8 months yielded a mean of 0.74 mg/L and a standard deviation of 0.029, thus we estimate that 95% of all samples at this level will have a range from + or - 0.06 (1.96 x 0.029) mg/L.