The Leeds Teaching Hospitals NHS Trust

Pathology

Voriconazole levels

Voriconazole levels

Use(s):

Confirmation of adequate levels and alerting to toxic levels in patients receiving voriconazole for treatment or prophylaxis of fungal disease.

Results:

Drug concentration in mg/L, with advice on target levels. Trough levels should be maintained between 1 - 5.5mg/L.  If levels are below this: ensure dosing is appropriate in relation to meals (if given orally) - consider increasing dose or examining effects of concomitant medications.

Note:

The uncertainty of measurement of this assay has been characterised in the following way, a positive control sample at the approximate level similar to the cutoff for a therapeutic leve, ie 1.0mg/L , tested over 6 months yielded a mean 1.17 of mg/L and a standard deviation of 0.08, thus we estimate that 95% of all samples at this level will have a range from + or - 0.15 (1.96 x 0.08 ) mg/L.