The Leeds Teaching Hospitals NHS Trust

Procollagen type 1 N propeptide (P1NP)

Procollagen type 1 N propeptide (P1NP)

Also known as procollagen extension peptide. Procollagen 1 (P1NP) concentrations reflect osteoblast activity so any disease increasing the activity of osteoblasts or activation frequency of the bone forming unit will result in elevated P1NP concentrations. Low P1NP may indicate adynamic bone. This test is currently only available to the Endocrinologists / bone clinic for monitoring response to anti-resorption therapy. P1NP shows minimal circadian rhythm or seasonal variation. Food intake or diet show no detectable influence on plasma levels. A baseline pre-treatment measurement is required if assessing response to antiresorption therapy.

Tube 04 (EP) - EDTA Plasma
ID Tests&Tubes0237
Additional Information If elevated, indicates high collagen formation.
Turn Around Turnaround time stated by Norfolk & Norwich: 2 weeks.
Send to Blood Sciences LGI
(Test referred to: Norfolk & Norwich University Hospital.)
Contact For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net.
Collection Con A single EDTA tube can be sent for both P1NP and CTX analysis. Instructions to lab: centifuge sample, separate plasma and freeze. Serum samples also acceptable fpr P1NP (but not for CTX).
Sample REQ Blood
Ref. Range Notes Male 20 - 76 ug/L. Female 19 - 69 ug/L.
Units ug/L
Telepath LGI superset LP1NP. SJUH superset JP1NP.