Topiramate is an anticonvulsant drug. It is rapidly and efficiently absorbed from the GI tract after which it is eliminated, predominantly unchanged, via the renal route with a plasma half life of 20-30 hrs. A proportion of the drug undergoes hepatic metabolism by oxidative pathways and the clearance is increased by enzyme inducing drugs. Clinical indication for measuring: Therapeutic drug monitoring (TDM) when modifying treatment or to establish baseline values. Also to check compliance or if toxicity is suspected.
|04 (EP) - EDTA Plasma
|Since large inter-individual differences exist between the dose required to achieve safe and effective plasma concentrations, and topiramate is often prescribed together with other AED’s which have similar CNS side-effects, the measurement of serum or plasma topiramate levels is a valuable aid to individualisation of treatment.
|Turnaround time stated by Cardiff toxicology lab: 7 days
|Blood Sciences LGI
(Test referred to: Cardiff toxicology lab)
|For further details please contact Leeds Pathology customer services: email@example.com.
|Full information on all referred tests can be found on the referred tests information database, EQMS reference BSF2REC17003.
|Instructions to lab: Centrifuge sample, separate plasma and store frozen. Serum gel tubes are not suitable.
Minimum volume: 1 mL plasma.
|Ref. Range Notes
|No code. Book in as PROB1L (comment NRSOT) & SA1R