Topiramate
Topiramate is an anticonvulsant drug. It is rapidly and efficiently absorbed from the GI tract after which it is eliminated, predominantly unchanged, via the renal route with a plasma half life of 20-30 hrs. A proportion of the drug undergoes hepatic metabolism by oxidative pathways and the clearance is increased by enzyme inducing drugs. Clinical indication for measuring: Therapeutic drug monitoring (TDM) when modifying treatment or to establish baseline values. Also to check compliance or if toxicity is suspected.
| Tube | 04 (EP) - EDTA Plasma |
|---|---|
| ID | Tests&Tubes0247 |
| Additional Information | Since large inter-individual differences exist between the dose required to achieve safe and effective plasma concentrations, and topiramate is often prescribed together with other AED’s which have similar CNS side-effects, the measurement of serum or plasma topiramate levels is a valuable aid to individualisation of treatment. |
| Turn Around | Turnaround time stated by Cardiff toxicology lab: 7 days |
| Send to | Blood Sciences LGI (Test referred to: Cardiff toxicology lab) |
| Contact | For further details please contact Leeds Pathology customer services: leedsth-tr.pathologycustomerservice@nhs.net. |
| Advice | Full information on all referred tests can be found on the referred tests information database, EQMS reference BSF2REC17003. |
| Collection Con | Instructions to lab: Centrifuge sample, separate plasma and store frozen. Serum gel tubes are not suitable. Minimum volume: 1 mL plasma. |
| Sample REQ | Blood |
| Ref. Range Notes | 5-20mg/L |
| Units | mg/L |
| Telepath | No code. Book in as PROB1L (comment NRSOT) & SA1R |
