Amyloid A Protein (SAA)
Serum Amyloid A (SAA) is released from hepatocytes in the acute phase and is the precursor of amyloid A fibrils which are found in amyloidosis (although levels are not predictive of fibril formation). Indicated in patients at risk of Amyloidosis e.g. Rheumatoid arthritis, Inherited Fever Syndromes.
|The concentration of SAA in the blood rises greatly in many inflammatory diseases, for example rheumatoid arthritis. Up to 10% of individuals with sustained high SAA values may eventually develop AA amyloidosis. Interpret in conjuction with clinical history, renal function and other acute phase proteins.
|See https://www.immqas.org.uk/TestItem.asp?id=62 for turn around time, allowing an additional 10 working days for sample processing and reporting.
|Samples should be sent to the department of Clinical Immunology at LGI who will refer to appropriate referral lab (Sheffield PRU)
|Turbid, icteric or lipaemic specimens are unsuitable.
|Referred to external laboratory
|Ref. Range Notes
|See reference range on referral website
|IP Acute TAT
|IP Routine TAT
|GP Acute TAT
|GP Routine TAT