Immunoglobulins (IgG, IgA, IgM)
There are three main immunoglobulin isotypes measured by the Immunology laboratory - IgG, IgA and IgM. n order deliver a cost effective service the departmental policy states that requests for immunoglobulins only should be made in the context of systemic inflammatory illnesses and immunodeficiency. Serum electrophoresis may be added at the validation stage if thought appropriate. We also recommend that requests for Serum Electrophoresis only are made if the identification or exclusion of a paraprotein in the serum (i.e. myeloma, MGUS, etc) is being investigated. Serum Immunoglobulin quantification is then only undertaken if a paraprotein is identified. It is recommended that a urine sample is provided to the laboratory WITH the serum sample to allow identification of free light chain (Bence Jones protein) in the urine if present
|Additional Information||IgE and IgD are only indicated in specific clinical circumstances. Interpret in the context of the age-related reference ranges.
Polyclonal increases in immunoglobulins can be seen in chronic infections, autoimmune diseases, and many tumours cause increases in polyclonal immunoglobulins. Skin, pulmonary and gut diseases are more likely to cause increases in IgA concentrations while systemic infections will increase all immunoglobulins but particularly IgG.
|Turn Around||7 days|
|Send to||Leeds General Infirmary
Old Medical School
Great George Street
|Collection Con||Instructions for Lab Staff: Standard lab processing - No special requirements
|Ref. Range (Male)||IgG = 6 - 16g.L IgA = 0.8 - 4g/L IgM = 0.5 - 2g/L|
|Ref. Range (Female)||IgG = 6 - 16g.L IgA = 0.8 - 4g/L IgM = 0.5 - 2g/L|
|Ref. Range (Paed)||See reference range note|
|Ref. Range Notes||Age specific - see report form.
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||7 days|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||7 days|