Oligoclonal bands CSF
The diagnosis of Multiple Sclerosis (MS) can be supported by the presence of oligoclonal bands in the CSF. The presence of IgG oligoclonal bands confined to the CSF (i.e. absent from a paired serum or with bands in addition to those found in a paired serum) is indicative of local immunoglobulin synthesis within the CSF.
|Additional Information||In MS patients, plasma cells residing within the CNS secrete IgG immunoglobulins into to CSF. Serum immunoglobulins are also present in low concentration in the CSF. Isoelectric focusing is used to detect IgG oligoclonal bands within the CSF and serum. Over 90% of patients with clinically definite Multiple Sclerosis have CSF IgG Oligoclonal bands.
However CSF IgG Oligoclonal bands are not specific for MS and have been described in many other disorders including various infective and inflammatory diseases of the CNS e.g. viral encephalitis, bacterial meningitis, neurosyphilis and SLE, however, in most of these diseases oligoclonal bands are uncommon.
|Turn Around||28 days|
|Send to||Leeds General Infirmary
Old Medical School
Great George Street
|Collection Con||Paired CSF and serum samples are required.|
|Sample REQ||CSF & Blood|
|Ref. Range (Male)||NA Interpretive|
|Ref. Range (Female)||NA Interpretive|
|Ref. Range (Paed)||NA Interpretive|
|Ref. Range Notes||Positive/Negative
|Units||- Not Defined -|
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||28 days|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||28 days|
|Telepath||SIMM1L and IEFC1L|
|ICE Codes||IIEFS and IIEFC|